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Risk of seizure (in co-administration with SSRI and TCA or others opioid). Tramadol usage may increase the risk of seizure in patients who also take therapy with MAO inhibitor, serotonin and reuptake inhibitor, neuroleptic and other drug that reduce the threshold of seizures.
Anaphylactoid reaction and respiratory depression. Increase intracranial pressure or head injury. Alcohol. Patients with hepatic impairment. Taken with another medicine contains paracetamol may increase the potential of toxicity. Withdrawal syndrome (discontinue this product gradually). Pregnancy & lactation. Elders.
